Plural - Revista Acadêmica

Resumo

A microbiota intestinal possui grande importância porque auxiliam na digestão, absorção de nutrientes, produção de muco, na defesa/sistema imunológico, manutenção da mucosa intestinal. A sua formação ocorre no momento do parto. Quando ocorre alteração nesta microbiota temos a disbiose. A disbiose pode levar a alterações no funcionamento do sistema nervoso central e isso levar a problemas como a depressão, ansiedade. O tratamento para a disbiose se faz com prebióticos ou probiótico. Ainda são necessários mais estudos para compreender a relação entre microbiota e sistema nervoso, mas é fato que precisamos dar uma atenção especial a nossa microbiota.

Palavras-chave: microbiota, disbiose, sistema nervoso central.

Referências

Rinninella E, Raoul P, Cintoni M, Franceschi F, Miggiano GAD, Gasbarrini A, Mele MC. What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases. Microorganisms. 2019 Jan 10;7(1):14. doi: 10.3390/microorganisms7010014. PMID: 30634578; PMCID: PMC6351938.

Thursby E, Juge N. Introduction to the human gut microbiota. Biochem J. 2017 May 16;474(11):1823-1836. doi: 10.1042/BCJ20160510. PMID: 28512250; PMCID: PMC5433529.

Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature. 2006 Dec 21;444(7122):1022-3. doi: 10.1038/4441022a. PMID: 17183309.

hosravi A, Mazmanian SK. Disruption of the gut microbiome as a risk factor for microbial infections. Curr Opin Microbiol. 2013 Apr;16(2):221-7. doi: 10.1016/j.mib.2013.03.009. Epub 2013 Apr 15. PMID: 23597788; PMCID: PMC5695238.

Arumugam, M.; Raes, J.; Pelletier, E.; Le Paslier, D.; Yamada, T.; Mende, D.R.; Fernandes, G.R.; Tap, J.; Bruls, T.; Batto, J.M.; et al. Enterotypes of the human gut microbiome. Nature 2011, 473, 174–180.

Kennedy, P. J., Cryan, J. F., Dinan, T. G., & Clarke, G. (2017). Kynurenine pathway metabolism and the microbiota-gut-brain axis. Neuropharmacology, 112, 399–412. doi:10.1016/j.neuropharm.2016.07.002.

Osadchiy V, Martin CR, Mayer EA. The Gut-Brain Axis and the Microbiome: Mechanisms and Clinical Implications. Clin Gastroenterol Hepatol. 2019 Jan;17(2):322-332. doi: 10.1016/j.cgh.2018.10.002. Epub 2018 Oct 4. PMID: 30292888; PMCID: PMC6999848.

Yatsunenko, T.; Rey, F.E.; Manary, M.J.; Trehan, I.; Dominguez-Bello, M.G.; Contreras, M.; Magris, M.; Hidalgo, G.; Baldassano, R.N.; Anokhin, A.P.; et al. Human gut microbiome viewed across age and geography. Nature 2012, 486, 222–227.

Weiss GA, Hennet T. Mechanisms and consequences of intestinal dysbiosis. Cell Mol Life Sci. 2017 Aug;74(16):2959-2977. doi: 10.1007/s00018-017-2509-x. Epub 2017 Mar 28. PMID: 28352996.

Kim S, Jazwinski SM. The Gut Microbiota and Healthy Aging: A Mini-Review. Gerontology. 2018; 64(6):513-520. doi: 10.1159/000490615. Epub 2018 Jul 19. PMID: 30025401; PMCID: PMC6191326.

Phillips, J. (1910). The Treatment of Melancholia by the Lactic Acid Bacillus. Journal of Mental Science, 56(234), 422-430. doi:10.1192/bjp.56.234.422.

Evrensel and K.N. Tarhan, Emerging role of Gut-microbiota brain axis in depression and therapeutic implication, Progress in Neuropsychopharmacology & Biological Psychiatry (2020), https://doi.org/10.1016/ j.pnpbp.2020.110138.

Kang YB, Cai Y, Zhang H. Gut microbiota and allergy/asthma: From pathogenesis to new therapeutic strategies. Allergol Immunopathol (Madr). 2017 May-Jun;45(3):305-309. doi: 10.1016/j.aller.2016.08.004. Epub 2016 Oct 28. PMID: 28029408.

Foster JA, McVey Neufeld KA. Gut-brain axis: how the microbiome influences anxiety and depression. Trends Neurosci. 2013 May;36(5):305-12. doi: 10.1016/j.tins.2013.01.005. Epub 2013 Feb 4. PMID: 23384445.

Srikantha P, Mohajeri MH. The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder. Int J Mol Sci. 2019 Apr 29;20(9):2115. doi: 10.3390/ijms20092115. PMID: 31035684; PMCID: PMC6539237.

Iannone, L F, Maria Gómez-Eguílaz, Rita Citaro & Emilio Russo (2020): The potential role of interventions impacting on gut-microbiota in epilepsy, Expert Review of Clinical Pharmacology, DOI: 10.1080/17512433.2020.1759414.

Quigley EMM. Microbiota-Brain-Gut Axis and Neurodegenerative Diseases. Curr Neurol Neurosci Rep. 2017 Oct 17;17(12):94. doi: 10.1007/s11910-017-0802-6. PMID: 29039142.

Goyal D, Ali SA, Singh RK. Emerging role of gut microbiota in modulation of neuroinflammation and neurodegeneration with emphasis on Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 2;106:110112. doi: 10.1016/j.pnpbp.2020.110112. Epub 2020 Sep 16. PMID: 32949638.

Caputi V, Giron MC. Microbiome-Gut-Brain Axis and Toll-Like Receptors in Parkinson's Disease. Int J Mol Sci. 2018 Jun 6;19(6):1689. doi: 10.3390/ijms19061689. PMID: 29882798; PMCID: PMC6032048.

Van de Sande, Marijke M. H.; VAN BUUL, Vincent J.; BROUNS, Fred J. P. H. Autism and nutrition: the role of the gut–brain axis. Nutrition Research Reviews, Cambridge, v. 27, p. 199-214, dez. 2014.

Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci. 2012 Oct;13(10):701-12. doi: 10.1038/nrn3346. Epub 2012 Sep 12. PMID: 22968153.

Lyte M. Probiotics function mechanistically as delivery vehicles for neuroactive compounds: Microbial endocrinology in the design and use of probiotics. Bioessays. 2011 Aug;33(8):574-81. doi: 10.1002/bies.201100024. Epub 2011 Jul 6. PMID: 21732396.

Roshchina VV. 2010. Evolutionary considerations of neurotransmitters in microbial, plant, and animal cells. In Lyte M, Freestone PPE, eds; Microbial Endocrinology: Interkingdom Signaling in Infectious Disease and Health. New York: Springer. pp. 17–52.

Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16050-5. doi: 10.1073/pnas.1102999108. Epub 2011 Aug 29. PMID: 21876150; PMCID: PMC3179073.

Zeng MY, Inohara N, Nuñez G. Mechanisms of inflammation-driven bacterial dysbiosis in the gut. Mucosal Immunol. 2017 Jan;10(1):18-26. doi: 10.1038/mi.2016.75. Epub 2016 Aug 24. PMID: 27554295; PMCID: PMC5788567.

Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell. 2011 May 27;145(5):745-57. doi: 10.1016/j.cell.2011.04.022. Epub 2011 May 12. PMID: 21565393; PMCID: PMC3140910.

Silva, Caroline Queiróz et al. Avaliação do perfil psicopatológico de acadêmicos de medicina e sua correlação com níveis de cortisol. Brazilian Journal of Development, v. 7, n. 4, p. 43490-43510, 2021.

Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology. 2007 Jan;132(1):397-414. doi: 10.1053/j.gastro.2006.11.002. PMID: 17241888.

Cardoso, F eta al. Expression of the enzyme indoleamine-2,3-dioxygenase in Rainbow Trout (Oncorhynchus mykiss). Pesq. Vet. Bras. 35 (10) - Out 2015.

Golubeva AV, Moloney RD, O'Connor RM, Dinan TG, Cryan JF. Metabotropic Glutamate Receptors in Central Nervous System Diseases. Curr Drug Targets. 2016;17(5):538-616. doi: 10.2174/1389450116666150316224011. PMID: 25777273.

Berger M, Gray JA, Roth BL. The expanded biology of serotonin. Annu Rev Med. 2009; 60:355-66. doi: 10.1146/annurev.med.60.042307.110802. PMID: 19630576; PMCID: PMC5864293.

Slykerman RF, Hood F, Wickens K, et al. Effect of Lactobacillus rhamnosus HN001 in pregnancy on postpartum symptoms of depression and anxiety: a randomised double-blind placebo-controlled trial. EBioMedicine 2017; 24:159–165. [PubMed: 28943228].

Schmidt K, Cowen PJ, Harmer CJ, et al. Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers. Psychopharmacology (Berl) 2015; 232:1793–1801. [PubMed: 25449699].

Tillisch K, Labus J, Kilpatrick L, et al. Consumption of fermented milk product with probiotic modulates brain activity. Gastroenterology 2013; 144:1394–1401, 401 e1–4. [PubMed: 23474283].

Desbonnet L, Garrett L, Clarke G, et al. Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience 2010; 170:1179–1188. [PubMed: 20696216].

Martínez-González A E; Andreo-Martínez, P. Prebiotics, probiotics and fecal microbiota transplantation in autism: A systematic review. Revista de Psiquiatría y Salud Mental (English Edition), Volume 13, Issue 3, July–September 2020, Pages 150-164.